School of Basic Sciences

Manaswini Ghosh

Peptide Biology, Structural Biology, Protein-protein Interactions

“1.Ghosh, M., Gupta, P.K., Jena, S. and Rana, S., 2024. The Interaction of Methotrexate with the Human C5a and its Potential
Therapeutic Implications. Computational Biology and Chemistry, p.108283.
2. Ghosh, M., Gupta, P.K., Behera, L.M. and Rana, S., 2024. Structure of Designer Antibody-like Peptides Binding to the Human
C5a with Potential to Modulate the C5a Receptor Signaling. Journal of Medicinal Chemistry, 67(16), pp.14110-14124.
3. Behera, L.M., Gupta, P.K., Ghosh, M., Shadangi, S. and Rana, S., 2024. A Rationally Designed Synthetic Antiviral Peptide
Binder Targeting the Receptor-Binding Domain of SARS-CoV-2. The Journal of Physical Chemistry B, 128(19), pp.4631-
4645.
4. Ghosh, M., Shadangi, S. and Rana, S., 2024. Rational design of antibody‐like peptides for targeting the human complement
fragment protein C5a. Proteins: Structure, Function, and Bioinformatics, 92(4), pp.449-463.
5. Behera, L.M., Ghosh, M., Gupta, P.K. and Rana, S., 2024. A rationally engineered small antimicrobial peptide with potent
antibacterial activity. Journal of Cellular Biochemistry, 125(2), p.e30503.
6. Ghosh, M., and Rana, S., 2023. The anaphylatoxin C5a: Structure, function, signaling, physiology, disease, and therapeutics.
International Immunopharmacology, 118, p.110081.
7. Das, A., Ghosh, M., Gupta, P.K. and Rana, S., 2023. Neutraligands of C5a can potentially occlude the interaction of C5a with
the complement receptors C5aR1 and C5aR2. Journal of Cellular Biochemistry, 124(2), pp.266-281.
8. Behera, L.M., Ghosh, M., and Rana, S., 2022. Deciphering the conformational landscape of few selected aromatic noncoded
amino acids (NCAAs) for applications in rational design of peptide therapeutics. Amino Acids, 54(8), pp.1183-1202.”

“National Conferences
Presented a poster at IMMUNOCON 2024 from 17th to 20th October at IISc Bengaluru, India.
Presented a poster at the 3rd QUAD Bhubaneswar on 10th August 2024 at NISER Bhubaneswar, India.
Presented a poster at the 1st KIIT-CRSI Conference on ‘Modern trends in Chemical Sciences’ on 5th September 2023 at KIIT, Bhubaneswar, India.
Presented a poster at the 9th Indian Peptide Symposium & INDIA PEPTIDE SHOW from 23rd-25th February 2023 at BITS, Pilani, Goa, India.

International Conference
Presented a poster at the Gordon Research Seminar (GRS) and Gordon Research Conferences (GRC) on ‘Chemistry and Biology of Peptides’ from 10th to 16th February 2024 at Ventura Beach Marriott, Ventura, California, United States.”

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