School of Basic Sciences

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Department of
Chemistry
School of Basic Sciences

Dr. Soumendra Rana

Associate Professor
  • Office: 314, SBS
  • +91-674-7135154
  • soumendra@iitbbs.ac.in
  • Department of Chemistry
IRINS Profile
Brief Resume
Google Scholar
Personal Website
Research Interests:
Structure Function Studies on Peptide or Protein binding G-protein Coupled Receptors. Rational Design of Peptides / Proteins as Therapeutics (Antimicrobial / Antiviral / Anti-inflammatory).Chemical and Cellular Biology. Computational Biology.
Education
Degree Discipline Year School
  Ph.D. Molecular Biophysics 2007 Indian Institute of Technology Bombay
  • Advanced Instrumentation Lab (CY5P004)
  • Biochemistry (CY7L001)
  • Biosciences (CYA2001)
  • B. Tech Chemistry Lab (CY1P001)
  • Chemistry (CY1L001)
  • Chemical Biology of Receptors (CY7L016)
  • Computational Methods & Application (CY5L009)
  • Genetic Engineering (CY3L001)
  • Introduction to Biosciences & Technology (ID2L001)
  • Organic Chemistry Lab (CY5P001)
  • Physical Methods in Inorganic Chemistry (CY7L006)
  • Receptor Pharmacology & Drug Discovery (CY7L020)
  • Structure Function of Biomolecules (CY7L019)
Ph.D: 6 graduated; 2 (Advanced Stage), 2 continuing
M.Sc: 11 graduated; 1 continuing
B.Tech: 1 completed
Winter Interns: 5 completed
Summer Interns: 1 completed
  • Associate Editor, Journal of Molecular Histology (Springer Nature)
  • Member of the International Chemical Biology Society
  • Life Member of Society of Biological Chemists, India
  • Life Member of Indian Peptide Society
  • Life Member of American Peptide Society
  1. Rational Design, Synthesis, Structural and Biological Evaluations of Non-coded Amino acid (NCAA) Containing Peptides as Potential Anti-inflammatory and Antimicrobial Agents; (Under evaluation, SERB)
  2. Rational Design of Targeted Peptide Antibodies against hC5a, including Broad Spectrum Antiviral Peptides Potentially Targeting SARS-CoV-2  Spike Protein (Apr-Dec 2020); Sponsoring Agency-IIT Delhi, India.
  3. Structural Studies on the Interaction of hC5a with the N-terminus Peptides of C5aR and C5L2 Receptor (2017-2020); Sponsoring Agency-DST, New Delhi, India
  4. Structure-Function studies of Extra Cellular Loop 2 (ECL2) of C5aR and C5L2 receptors (2013-2015); Sponsoring Agency-IIT Bhubaneswar, India

 

  1. Singh, A.; Shadangi, S.; Rana, S. G-protein Coupled Receptors in Neuroinflammation, Neuropharmacology, and Therapeutics. Biochemical Pharmacology, 2025, 242(2), 117301.
  2. Shadangi, S.; Singh, A.; Rana, S. Deciphering the Mechanism of Action of a Short, Synthetic Designer AMP against Gram-negative Bacteria. Biopolymers, 2025, 116(3):e70019.
  3. Gupta, P.; Singh, A.; Rana, S. Interaction of Phosphorylated C5aR1 with β-Arrestin1: A Comparative Structural Modeling Study. Proteins, 2025, 93(11):2015-2033. (Featured on the Cover Page of the Journal).
  4. Singh, A.; Shadangi, S.; Gupta, P.; Rana, S. Type II Diabetes Mellitus: A Comprehensive Review of Pathophysiology, Comorbidities, and Emerging Therapies. Comprehensive Physiology, 2025, 15(1):e70003.
  5. Ghosh, M; Gupta, P. K.; Jena, S.; Rana, S. The Interaction of Methotrexate with the Human C5a and its Potential Therapeutic Implications. Comput. Biol. Chem. 2025, 114:108283.
  6. Ghosh, M; Gupta, P. K.; Behera, L. M.; Rana, S. Structure of Designer Antibody-like Peptides Binding to the Human C5a with Potential to Modulate the C5a Receptor Signaling. J. Med. Chem. 2024, 67(16):14110-14124.
  7. Behera, L. M.; Gupta, P. K.; Ghosh, M; Shadangi, S; Rana, S. A Rationally Designed Synthetic Antiviral Peptide Binder Targeting the Receptor Binding Domain of SARS-CoV2. J. Phy. Chem. B. 2024, 128(19):4631-4645.
  8. Gupta, P.; Singh, A.; Rana, S. Conformational variants of the Ternary complex of C5a, C5aR1, and G-protein. J. Bimol. Struct. Dyn. 2025, 43(10):4885-4900.
  9. Ghosh, M.; Shadangi, S.; Rana, S. Rational Design of Antibody-like Peptides for Targeting the Human Complement Fragment Protein C5a. Proteins, 2024; 92(4):449-463.
  10. Behera, L. M.; Ghosh, M; Gupta, P. K.; Rana, S. A Rationally Engineered Small Antimicrobial Peptide with Potent Antibacterial Activity. J. Cell. Biochem. 2024, 125(2):e30503
  11. Gupta, P.; Das, A.; Singh, A.; Rana, S. Ternary Model Structural Complex of C5a, C5aR2, and Beta-Arrestin1. J. Bimol. Struct. Dyn. 2024, 42(14):7190-7206.
  12. Ghosh, M.; Rana, S. The anaphylatoxin C5a: Structure, Function, Signaling, Physiology, Disease, and Therapeutics. Int. Immunopharmacol. 2023, 118, 110081.
  13. Das, A.; Ghosh, M.; Gupta, P.; Rana, S. Neutraligands of C5a can Potentially Occlude the Interaction of C5a with the Complement Receptors C5aR1 and C5aR2. J. Cell. Biochem. 2023, 124 (2), 266-281.
  14. Das, A.; Gupta, P.; Rana, S. C5aR2 Receptor: The Genomic Twin of the Flamboyant C5aR1. J. Cell. Biochem. 2022, 123(11), 1841-1856.
  15. Behera, L. M.; Ghosh, M.; Rana, S. Deciphering the Conformational Landscape of Few Selected Aromatic Non-Coded Amino acids (NCAAs) for Applications in Rational Design of Peptide Therapeutics. Amino Acids, 2022, 54, 1183-1202.
  16. Das, A.; Behera, L. M.; Rana, S. “Interaction of Human C5a with the Major Peptide Fragments of C5aR1: Direct Evidence in Support of a “Two-Site” Binding Paradigm”. ACS Omega, 2021, 6(35): 22876-22887.
  17. Das, A.; Rana, S. “The Role of Human C5a as a Non-genomic Target in Corticosteroid Therapy for Management of severe COVID19”. Comput. Biol. Chem. 2021, 92, 107482.
  18. Mishra, R.; Behera, L. M.; Rana, S. “Binding of Raloxifene to Human Complement fragment 5a (hC5a): A Perspective on Cytokine Storm and COVID19”. J. Bimol. Struct. Dyn. 2020, 15, 1-13.
  19. Mishra, R.; Das, A.; Rana, S. “Resveratrol Binding to Human Complement fragment 5a (hC5a) may Modulate the C5aR Signaling”. J. Bimol. Struct. Dyn. 2020, 17, 1-15.
  20. Mishra, R.; Rana, S. “A Rational Search for Discovering Potential Neutraligands of Human Complement fragment 5a (hC5a).” Bioorg. Med. Chem. 2019, 27, 115052
  21. Sahoo, A.; Mishra, R.; Rana, S. “The Model Structures of the Complement Component 5a Receptor (C5aR) Bound to the Native and Engineered hC5a.” Sci. Rep. 2018, 8, 2955.
  22. Rana, S.; Sahoo, A.; Majhi, B. “Structural Complexes of Agonist, Inverse Agonist and Antagonist Bound C5a Receptor: Insights into Pharmacology and Signaling.” Mol. BioSyst. 2016, 12, 1586-1599.
  23. Rana, S.; Sahoo, A.; Majhi, B. “Allosterism in human Complement Component 5a (hC5a): A Damper of C5a Receptor (C5aR) Signaling.” J. Bimol. Struct. Dyn. 2015, 1-13.
  24. Rana, S.; Sahoo, A. “Model structures of inactive and peptide agonist bound C5aR: Insights into agonist binding, selectivity and activation.” Biochem. Biophy. Rep. 2015, 1, 85-96.
  25. Kumar SS; Rana S; Nangia A. “Solid-state form screen of cardiosulfa and its analogues”. Chem Asian J. 2013, 8, 1551-68.
  26. Akiri, K.; Cherukuvada, S.; Rana, S.; Nangia, A.”Crystal Structures of Pyridine Sulfonamides and Sulfonic Acids.” Cryst. Growth Des. 2012, 12, 4567-73.
  27. Rana, S.; Yang, L; Hassanian, S. M.; Rezaie A. R. “Determinants of the Specificity of Protease-activated Receptors-1 and 2 Signaling by Factor Xa and Thrombin.” J. Cell. Biochem. 2012, 113, 977-84.
  28. Rana, S.; Baranski, T. J. “Third Extracellular Loop (EC3)-N terminus Interaction is Important for 7TM Receptor Function: Implication for an Activation ‘Microswitch’ Switch Region.” J. Biol. Chem. 2010, 285, 31472-83.
  29. Rana, S.; Kundu, B.; Durani, S. “A Synthetic Cholinergic Receptor of Mixed-L, D Residues Exceptionally Small and Simple.” Biopolymers 2007, 87, 231-243.
  30. Rana, S.; Kundu, B.; Durani, S. “A Double Catgrip Mixed L and D Mini Protein Only 20 Residues Long.” Bioorg. Med. Chem. 2007, 15, 3874-3882.
  31. Joshi, S.; Rana, S.; Wangikar, P.; Durani, S. “Computational Design of Proteins Stereochemically Optimized in Size, Stability and Folding Speed”. Biopolymers 2006, 83, 122-134. (Designed THBs were Featured on the Cover Page of Biopolymers).
  32. Rana, S.; Kundu, B.; Durani, S. “A Small Peptide Stereochemically Customized as a Globular Fold with a Molecular Cleft”. Chemical Communications 2005, 11, 207-209. (Featured as Hot article by Royal Society of Chemistry and as news in Chem. Sci. and Chemistry World, Dec 26, 2004)
  33. Rana, S.; Kundu, B.; Durani, S. “Stereospecific Peptide Folds. A Rationally Designed Molecular Bracelet.” Chemical Communications 2004, 21, 2462-2463.
Book Chapters

1. Singh, A.; Shadangi, S.; Bagh, S.; Rana, S. “Engineered Antibodies: The Molecular Workhorses of the Immune System as Therapeutics”. 2025, in “COMPUTATIONAL AND EXPERIMENTAL APPROACHES IN PROTEIN ENGINEERING AND DESIGN”, Academic Press (Submitted).

Patents
  1. Rana S., An Engineered Antimicrobial Peptide (AMP), Patent pending (No: 202331049857)

1: Washington University School of Medicine in Saint Louis, Missouri, USA

2: Saint Louis University School of Medicine, Missouri, USA

3: University of Arizona, Tucson, Arizona, USA

Patents

  1. Rana S., An Engineered Antimicrobial Peptide (AMP), Patent pending (No: 202331049857)
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