Dr. Anasuya Roychowdhury is a faculty member in the School of Basic Sciences where she is the Principal Investigator of the Biochemistry and Cell Biology Laboratory.
Dr. Roychowdhury received her M.Sc. and M.Tech. from Visva-Bharati, Santiniketan and Jadavpur University, Kolkata. Her M.Tech project under the supervision of Dr. Alok Kumar Datta at the Indian Institute of Chemical Biology (IICB), Kolkata, inspired her to pursue a career in research. She then moved to United States to carry out her Ph.D. at the University of Texas Medical Branch (UTMB), Galveston, Texas under the guidance of Prof. Wlodek Bujalowski in the department of Biochemistry & Molecular Biology. Her study was focussed on ATPase Biochemistry (interaction of DnaB helicase–DnaC protein complex) in DNA replication. She then moved to Boston to carry out her postdoctoral research in the laboratory of Prof. Daniel Finley at Harvard Medical School. In her postdoctoral project, she studied the Biochemistry of AAA+ ATPases (Rpt 1-6) and deubiquitinase (DUB) enzyme Ubp6 in proteasome mechanism and function. Dr. Roychowdhury returned to India in 2013 to join IIT Bhubaneswar as an Assistant Professor in Chemistry and Biosciences in the School of Basic Sciences, and currently serves as an Associate Professor in the same department. Her present research focuses on the regulation and mechanism of the AAA+ ATPase ATAD2 in gastrointestinal (stomach, pancreatic, and colorectal) cancer. She also studies the gut microbiome and probiotic intervention strategies for the prevention of colorectal cancer. Together, her research spans a multidisciplinary arc from Biochemistry to Cell Biology and from Cancer Biology to Microbiology and Bioinformatics.

Undergraduate (B.Tech.) Courses:
• An Introduction to Bioscience & Technology [BS2L001, Core]: B.Tech. and Dual Degree 1st semester (2-0-0)
• Genetic Engineering [CY3L001, Lateral]: B. Tech. and Dual Degree 6th Semester (3-0-0)
• Chemistry Laboratory [CY5S001]: B.Tech.and Dual Degree 1st semester (0-0-3)
Undergraduate ITEP (Chemistry) Course:
• Pedagogy of Chemistry-3 [CY3L306, Core] : ITEP (Chemistry) 4th semester (0-0-2)
Post-graduate (M.Sc./Ph.D.) Courses:
• Chemistry of Pharmaceutics [CY7L030, Elective]: Joint M. Sc. Chemistry/Ph.D. course (3-0-0)
• Biochemistry [CY7L001, Elective]: Joint M. Sc. Chemistry/Ph.D. course (3-0-0)
• Thermodynamics and Chemical Equilibrium [CY5L005, Core]: M.Sc. Chemistry (3-1-0)
• Literature survey & seminar I [CY5S001]: M.Sc. Chemistry (0-0-3)
• Advanced Instrumentation Laboratory [CY5P004]: M.Sc. Chemistry (0-0-6)
• Physical Chemistry Laboratory [CY5L003]: M.Sc. Chemistry (0-0-6)

Ph. D. students: 3 completed
M.Sc. project students: 8 completed
Interns: 8 completed (including 2, J&K Interns)

1. ASPIRE Grant (2025-28) entitled “Understanding the function and mechanism of hypoxia-responsive ATAD2 in colorectal cancer cells”. Sponsoring Agency: CSIR, India. Role: PI (on going).
2. Extramural Ad-Hoc Grant (2021-24) entitled “Identification, synthesis and validation of potential ATAD2 ligands as a therapeutic strategy for stomach cancer”. Sponsoring Agency: ICMR, India. Role: PI (completed).
3. R&D grant (2020-23) entitled “Functional Consequences of Cancer Testis Antigen ATAD2 in Pancreatic Cancer”. Sponsoring Agency: DBT, India. Role: PI (completed).
4. Vanderbilt International Research Grant (2015-17) entitled “The Role of Clock ATPase KaiC in the Temporal Control of DNA Replication” Sponsoring Agency: Vanderbilt International Research Grants Program, Vanderbilt University, USA. Role: PI (completed).
5. Seed Money Project (2014-16) entitled “Chemo-mechanistic Physiology and Regulation of KaiC ATPase”. Sponsoring Agency: IIT Bhubaneswar; Role: PI (completed).
6. Indo-US Joint Centre (2014-2017) on “Nanostructure Genomics: Designing Functionality of 2-Dimensional Nanostructures and Nano-Bio Interfaces”. Sponsoring Agency: The Indo-US Science and Technology Forum (IUSSTF); Role: co-PI (completed).

Journal Articles

1. Circadian disruption in colorectal cancer: Promise of chronotherapy as precision medicine. Paul R, Roychowdhury A. Biochem Biophys Res Commun. 2026; 823:153923 [Invited Review; Q2; IF=2.5].
2. WGS analysis and functional studies illustrate promising gene-signatures for probiotic attributes and molecular-targeted therapeutic prospects of Lactiplantibacillus plantarum LP-ARP2. Patra S, Patra R, Das PK, Dixit A, Roychowdhury A. Arch Microbiol. 2026; 208:125 [Q2; IF=3.4].
3. Complete genome sequence, metabolic profiling and functional studies reveal Ligilactobacillus salivarius LS-ARS2 is a promising biofilm-forming probiotic with significant antioxidant, antibacterial, and antibiofilm potential. Patra S, Pradhan B, Roychowdhury A. Front Microbiol. 2025; 16:1535388 [Q1; IF=5.8].
4. A study of a survival data using kernel estimates of hazard rate and aging intensity functions. Szymkowiak M, Roychowdhury A, Misra SK, Giri RL, Bhattacharjee S. Statistics in Transition New Series. 2023;24(5):109-127 [Q4; IF=0.5].
5. ATAD2 Suppression Enhances the Combinatorial Effect of Gemcitabine and Radiation in Pancreatic Cancer Cells. Dutta M, Mohapatra D, Mohapatra AP, Senapati S, Roychowdhury A. Biochem Biophys Res Commun. 2022; 635:179-186 [Q2; IF=3.1].
6. MicroRNA-217 Modulates Pancreatic Cancer Progression via Targeting ATAD2. Dutta M, Das B, Mohapatra D, Behera P, Senapati S, Roychowdhury A. Life Sci. 2022;301:120592 [Q1; IF=6.1].
7. Effects of Probiotics at the Interface of Metabolism and Immunity to Prevent Colorectal Cancer-Associated Gut Inflammation: A Systematic Network and Meta-Analysis With Molecular Docking Studies. Patra S, Sahu N, Saxena S, Pradhan B, Nayak SK, Roychowdhury A. Front Microbiol. 2022;13:878297 [Q1; IF=5.2] .
8. Emerging oncogene ATAD2: Signaling cascades and therapeutic initiatives. Nayak A, Dutta M, Roychowdhury A. Life Sci. 2021; 276:119322 [Q1; IF=6.78].
9. Systematic Network and Meta-analysis on the Antiviral Mechanisms of Probiotics: A Preventive and Treatment Strategy to Mitigate SARS-CoV-2 Infection. Patra S, Saxena S, Sahu N, Pradhan B, Roychowdhury A. Probiotics Antimicrob Proteins. 2021;13(4):1138-1156 [Q2; IF=5.4].
10. Oncogenic potential of ATAD2 in stomach cancer and insights into the protein-protein interactions at its AAA + ATPase domain and bromodomain. Nayak A, Kumar S, Singh SP, Bhattacharyya A, Dixit A, Roychowdhury A. J Biomol Struct Dyn. 2021 [Q2; IF=5.235].
11. HIF1α-dependent upregulation of ATAD2 promotes proliferation and migration of stomach cancer cells in response to hypoxia. Nayak A, Roy AD, Rout N, Singh SP, Bhattacharyya A, Roychowdhury A. Biochem Biophys Res Commun. 2020;523(4):916-923 [Q2; 3.575].
12. Mechanisms of Interactions of the Nucleotide Cofactor with the RepA Protein of Plasmid RSF1010. Binding Dynamics Studied Using the Fluorescence Stopped-Flow Method. Andreeva IE, Roychowdhury A, Szymanski MR, Jezewska MJ, Bujalowski W. Biochemistry. 2009;48(44):10620-36 [Q1; I.F=3.162].
13. Interactions of the E. coli DnaB−DnaC Protein Complex with Nucleotide Cofactors. 1. Roychowdhury A, Szymanski MR, Jezewska MJ, Bujalowski W. Biochemistry. 2009;48(29):6712-29 [Q1; I.F=3.162].
14. Mechanism of NTP Hydrolysis by the E. coli Primary Replicative Helicase DnaB Protein. 2. Roychowdhury A, Szymanski MR, Jezewska MJ, Bujalowski W. Biochemistry. 2009;48(29):6730-46 [Q1; I.F=3.162].
15. Escherichia coli DnaB helicase–DnaC protein complex: allosteric effects of the nucleotides on the nucleic acid binding and the kinetic mechanism of NTP hydrolysis. 3. Roychowdhury A, Szymanski MR, Jezewska MJ, Bujalowski W. Biochemistry. 2009;48(29):6747-63 [Q1; I.F=3.162].
16. Accumulation of p-hydroxybenzoic acid in hairy roots of Daucus carota Sircar D, Roychowdhury A, Mitra A. J Plant Physiol. 2007;164(10):1358-66 [Q1; I.F= 3.549].
17. Kinetic mechanisms of the nucleotide cofactor binding to the strong and weak nucleotide-binding site of the E. coli PriA helicase. Lucius AL, Jezewska MJ, Roychowdhury A, Bujalowski W. Biochemistry. 2006;45(23):7217-36 [Q1; I.F= 3.162].

Book Chapter

1. Mitra T., Mahapatra .S.S., Mishra B., Panda V.K., Malhotra D., Roychowdhury A.and Kundu G.C*. Hypoxia and Its Biological Implications for Cancer Therapy. In: Mukherjee, S., Kanwar, J.R. (eds). Springer, 1-18, 2023. https://doi.org/10.1007/978-981-99-0313-9_1

2. Dutta M, Patra S, Saxena S, Roychowdhury, A*. Antimicrobials: Targets, Functions and Resistance. Book chapter of “Biomolecular Engineering Solutions for Renewable Specialty Chemicals: Microorganisms, Products, and Processes”.In: R. Navanietha Krishnaraj, Rajesh K. Sani (eds) John Wiley & Sons, Inc.; pages 77-109; October 25, 2021. https://doi.org/10.1002/9781119771951.ch3

1. Patra S. and Roychowdhury A., Lactobacillus plantarum shows Probiotic Potential and Antioxidant properties for the Prevention of Colorectal Cancer. J. Biol. Chem. (2023) 299(3S) S53-54, https://doi.org/10.1016/j.jbc.2023.103169.
2. Roychowdhury A, Nayak A, Kumar S, Dixit A, BhattacharyyaA. Hypoxia-responsive and HIF1α-regulated AAA+ ATPase ATAD2 shows high oncogenic potential in stomach cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 5680. https://doi.org/10.1158/1538-7445.AM2022-5680
3. Nayak A, Kumar S, Bhattacharyya A, Dixit A, Roychowdhury A (2019). Cross-Cancer Study with a Special Emphasis on Stomach Cancer Reveals ATAD2 as Diagnostic and Prognostic Biomarker. Mol Biol Cell 30(26), pp. P-1150. https://doi.org/10.1091/mbc.E19-11-0617.
4. Roychowdhury A, Nayak A, Bhattacharyya A. (2019). AAA+ ATPase ATAD2 signalling networks in gastric cancer. Biochem Mol Biol J Vol.5; doi: 10.21767/2471-8084-C3-029.
5. Roychowdhury A, Robert J, Lee BH, Finley D. Characterization of the Non-catalytic Inhibitory Effect of Ubp6 on Proteasome Function. FASEB J. 27:553.23, 2013.
6. Roychowdhury A, Jezewska MJ, Bujalowski W. Nucleotide Control of Replication Initiation: NTPase Mechanisms of E.coli DnaB-DnaC Complex. Biophysical J., vol. 96, issue 3, pp. 209a-209a, 2009.
7. Roychowdhury A, Jezewska MJ, Bujalowski W. (2009). E.coli DnaB-DnaC Complex with Nucleotide Cofactors: An Allosteric Control of Recognition Process in DNA Replication. Special Issue: The 23rd Symposium of The Protein Society 2009: Abstract 235, Protein Science. vol. 18, issue S1, pp 137.
8. Roychowdhury A, Jezewska MJ, Bujalowski W. (2008) Functional Studies of E.coli DnaB-DnaC Complex Indicates Its Role As a Part of Primosome. 2008 Biophysical Society Meeting Abstracts. Biophysical J., Supplement, vol. 94, issue 2, Abstract, pp. 675.
9. Lucius, AL, Jezewska MJ, Roychowdhury A, Bujalowski W. (2006) Kinetic Mechanisms of the nucleotide Cofactor binding to the Strong and Weak Nucleotide-Binding Site of the Escherichia coli PriA Helicase. 2006 Biophysical Society Meeting Abstracts. Biophysical J., Supplement, vol. 90, Abstract, 981-Pos.

• Associate Professor (Chemistry), School of Basic Sciences (SBS), IIT Bhubaneswar, India (2022-present).
• Assistant Professor (Chemistry & Bio-sciences), SBS, IIT Bhubaneswar, India (2013-2022).
• Post-doctoral Research Fellow, Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA. Mentor: Prof. Daniel J. Finley (2010-13).
• Graduate Assistant, Department of Biochemistry and Molecular Biology, Sealy Center for Structural Biology and Molecular Biophysics, The University of Texas Medical Branch (UTMB) at Galveston, Texas, USA. Mentor: Prof. Wlodek M. Bujalowski (2004-2009).
• Project Assistant, Natural Product Biotechnology Group, Agricultural and Food Engineering Department, IIT Kharagpur, India. Mentor: Dr. Adinpunya Mitra (2003-2004).

Presentation highlights [Total: 29]
International: Academia (12)
[Invited talks at Vanderbilt University, Yale University, MIT, Rockefeller University, Harvard University, University of California, San Diego, The National Cancer Institute (NCI)-NIH, Annual Biophysical Society Meeting, Annual Gibbs Conference on Biothermodynamics, Genetics and Genetic Disorders and Stem Cell at Stockholm (invited talk and session chair), The 5th Annual World Congress of Molecular & Cell Biology, Nanjing, China (invited talk and session chair) etc.].
National: Academia (14)
[Invited talks at International Conference on Translational Research (ICTR) meetings, National Academy of Sciences, India (NASI) and Indian National Science Academy (INSA) Local Chapter, Annual Convention of the Indian Association of Cancer Research (IACR), 160th Birth Anniversary Celebration of Acharya Prafulla Chandra Ray organized by the Indian Chemical Society, International Symposium on “Tumor Microenvironment and Cancer Prevention & Therapeutics” at JNU, Annual Meeting of Society of Biological Chemists (India) [SBCI], NICED-Kolkata, CCMB-Hyderabad, IIT Bombay, IIT Hyderabad, NII-Delhi, IIT Kharagpur, National Conference on Bioengineering at NIT Rourkela (invited talk and session chair) etc.].
National: Industry (3)
Veeda Lifesciences, Bangalore; Agilent Technologies, Bangalore; Imgenex India, Bhubaneswar

Review Activities
Reviewer for the international journals
Gut microbes (IF=11), Cancer Letters (IF=9.7), Frontiers in Immunology (IF=8.7), Frontiers in Cellular and Infection Microbiology (IF=6), Microbes and Infection (IF=5.8), Journal Of Enzyme Inhibition And Medicinal Chemistry (IF=5.7), Communications Biology (IF=5.1), Cancer Gene Therapy (IF=5), Frontiers in Oncology (IF=4.7), Beneficial Microbes (IF=5.4), British Journal of Nutrition (IF=4.1), BMC Medical Genomics (IF=3.6), Pancreatology (IF=3.6), Frontiers in Nutrition (IF=3.5), Oncology Reports (IF=3.9), Molecular Medicine Reports [IF=3.4], Oncology letters (IF=3.1), Scientific Reports (IF=3.8), Biomedical and Environmental Sciences (IF=3.0), Journal of Applied Microbiology (IF=3.2), Journal of Gastrointestinal Oncology (IF=2.5), Discovery oncology (IF=2.2), Histology and Histopathology (IF=2.1).
Grant reviewer: National
Member of the the subject expert committee for evaluation of proposals under WISE-PhD and WOS-A programs in the Life Science thematic area of Department of Science and Technology (DST), India (July 2025)
Reviewer for the funding scheme proposal (under Cancer research) of The Department of Biotechnology (DBT), India (June 2024)
Reviewer for the proposals under SITARE-Gandhian Young Technological Innovation Award Grant (SITARE-GYTI) 2021.
Grant reviewer: International
Reviewer for the funding scheme of National Science Centre (Narodowe Centrum Nauk), Poland (March 2023)

Membership in Scientific Societies:
• Life Member, Indian Association of Cancer Research (IACR)
• Life Member, Indian Society of Translational Research (ISTR)
• Life Member, The Society Of Biological Chemists India (SBCI)

Administrative Responsibilities
Selected Administrative activities at Institute level
1.Chairperson, Women Welfare Committee (WWC) (September 2025-present)
2.Treasurer, Gymkhana (May 2024- July 2026).
3.Nominated member of Senate (March 2023-May 2025).
4.Health and Sanitation Theme Leader of Unnat Bharat Abhiyan (UBA) team, (July 2021-June 2025).
5.DBT Approved Member Secretary of Institutional Bio-safety Committee (IBSC) of IIT Bhubaneswar (Nov 2017-March 2023).
6.Member, Task Force for Prevention of Spread of COVID-19, IIT Bhubaneswar (July 2020-2022).
7.Coordinator, “Ishan Vikas” scheme of MHRD, conducted by IIT Bhubaneswar, December 7-21, 2016.
Institute level science talks/pedagogical activities
1. Conducted theory and lab classes on Biology for JNV’s teacher training program (Dec 10-11 2025) conducted by IIT Bhubaneswar.
2. Delivered lectures on “Biological macromolecules” and “Antibacterials and Vaccines” (Dec 12 and Dec 13, 2024) for JNV’s teacher training program (Dec 10-21 2024) conducted by IIT Bhubaneswar.
3. Delivered talk entitled “The stories of the Nobel Women in Physiology or Medicine” (June 7, 2018) for “Vigyan Jyoti” Program, organized by IIT Bhubaneswar, funded by Department of Science and Technology (DST), India during June 4 – 24, 2018.
4. Delivered talk entitled “The Nobel Prize Winning Discoveries (2017) on Physiology /Medicine” for Special Institute Seminar Series on “Nobel Prize-2017” at IIT Bhubaneswar (November 14, 2017).
5. Delivered talk entitled “Healthcare in India” at “Ishan Vikas” Program of MHRD conducted by IIT Bhubaneswar (December 12, 2016).
Selected Administrative activities at the School/Departmental level
1. Departmental (Chemistry) Examination Coordinator (August 2026 to June 2028)
2. Faculty Advisor for M.Sc.(2024-26) Batch
3. Timetable Coordinator for School of Basic Sciences (2022-2025).
4. Timetable Coordinator for Chemistry, (2014-2025)
5. Coordinator (in rotation)/Member, Ph.D. (Bioscience) Admission Committee (2013-present)